yes I can
That what was written in the study:
Discussion :
In order to assess the relevancy of the measured propofol blood concentrations of this case they were compared to two fatal cases of propofol abuse reported in literature
.
the first case: a male nurse who injected himself rapidly , 11 ampules of 20ml propofol emulsion must have been taken
(2200mg propofol)
Blood : 5.3 ( cumulative effect was 1 ug/ml because of previous injections) ,
Liver: 27,
Urine: 5.4
The second case: concerned a female radiographer who was said to have
abused propofol for a prolonged period of time
Blood : 0.22 ( a long survival time) ,
Liver: 1.4,
Urine :5.4
The third case: the
suicide of a medical doctor who used two hypodemic needles in the back of his hand for an infusion of propofol.
Blood : 2.5 ( shorter survival time than the previous case)
Liver: 22,
Urine : N.D
The the fourth case : a 37-year-old Chinese male suspected of having fatally self-administered an intravenous dose of
1600 mg of propofol (12.3–15.4 times the dose required for the induction of anaesthesia)
Blood( femoral): 2.5,
Liver: 22,
Kidney (urine): 3.6.
MJ : Blood ( hospital) :4.1
, Femoral : 2.4
, Liver: 6.2
, Uirne 0.15 , Urine at the scene: 0.10
The first case (2200mg): at autopsy the bladder contained 250ml/h assuming a urine production of 40/50ml/h the bladder contents would have been produced within 6 hours and therefor would have been at least 12 injections of one ampule each within this time period.
MJ's case, the bladder contained (540ml) going by a production of 40/50ml/h , that amount was produced in 10 to 11 hours. So In the 10 to 11 hours before his death he received propofol, how much propofol?
If someone received 2200mg of propofol , had 250ml urine in his blader and propofol concentration of 5.4.
How much propofol did MJ recieve if his bladder contained 540ml urine and propofol concentration of 0.10 ?
Give me an estimation.
Notice, also in the case of the suicide, propofol was not detected in urine. So if MJ only received the injection that killed him, no propofol would have been detected in his urine . He must have received a VERY SMALL dose sometime during the last 10 hours, that's why I said he only induced sleep and then switched to other sedatives.
Is it clear now why I said MJ must have received less than 200mg that day ?
Read and compare. in order to assess you have to compare . Notice the blood concentrations were not an indication of how much they received. They could only determine how long survived after being injected.
As for the urine. Again four cases to compare , read the description of each one and the results and compare you will come to the same conclusion , he could have never received anything exceeding 200mg that day.
